Workshop on Phylogenetics for Infectious Diseases - with a focus on DNA viruses
(10 - 14 Oct 2011)

~ Abstracts ~

Some modeling issues in phylogenetics
Von Bing Yap, National University of Singapore


The Markov chain model of the substitution process in a sequence of DNA bases or codons will be briefly reviewed. Statistical detection of adaptive selection in a multiple alignment, given a phylogenetic tree, will be discussed. The models go back to the mid 1990?s, and have essentially stayed unchanged. A new class of models may alter this consensus. If time permits, the reconstruction of rooted phylogenies will be briefly discussed.

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