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Figuring Out Life:
NUS - Karolinska Joint Symposium on Application of Mathematics in Biomedicine
(28 - 29 Nov 2005)

 Organizer

  • Martti Tammi (National University of Singapore and Karolinska Institutet, Sweden)

 Speakers

  • Alan Christoffels (Temasek Life Sciences Laboratory, Singapore)
  • Carsten Daub (Karolinska Institutet, Sweden)
  • Amilcar Flores (Karolinska Institutet, Sweden)
  • Liam Good (Karolinska Institutet, Sweden)
  • Prasanna Kolatkar (Genome Institute of Singapore)
  • Vladimir A. Kuznetsov (Genome Institute of Singapore)
  • Boon-Chuan Low (National University of Singapore)
  • Piergiorgio Percipalle (Karolinska Institutet, Sweden)
  • Michael Raghunath (National University of Singapore)
  • Sara Sandin (Karolinska Institutet, Sweden)
  • David Siegmund (Stanford University and National University of Singapore)
  • Tin-Wee Tan (National University of Singapore)
  • Chandra Verma (Bioinformatics Institute of Singapore)
  • Lim-Soon Wong (National University of Singapore)

 Overview

This symposium aims to explore the twilight zone between mathematics and biology. The true complexity of biological organisms is only beginning to unfold; in living systems, a collection of properties emerges at each level of organization and in order to cope with the diversity at every scale of spatial and temporal organization, fundamental conceptual advances and interdisciplinary collaborations are inevitable. A thousand or so complete genome sequences are available and we are left with incredible puzzles to solve. Domain expertise is essential, but a powerful approach is to combine reductionist approaches with a holistic understanding. This is where mathematics and computational biology are an integral part of biological research.

Throughout the history mathematics has brought powerful insight in understanding the workings of biological systems. Perhaps the most well known example is the Hardy-Weinberg equilibrium in population genetics, which Hardy and Weinberg devised back in 1908. A more recent example is Kimura’s diffusion equation for gene frequencies in 1994. Mathematics has left many more deep footprints in biological research than is generally realized. For example, Markov models (Markov, 1906) are ubiquitously used in the post-genomics era of today and the list can be made long: age structure of stable populations (Euler, 1760), analysis of variance (Fisher, 1950), dynamics of interacting species (Lotka, 1925; Volterra, 1931), traveling waves in genetics (Fisher, 1937; Kolmogorov et al. 1937), distribution of bacterial mutation rates (Luria and Delbruck, 1943), morphogenesis (Turing, 1952), graph theory and genetic structure (Benzer, 1959), formula for haplotype frequencies (Ewens, 1972) and population coalescence (Kingman, 1982). The list is a mere example and can be made much longer. This interdisciplinary workshop represents a unique opportunity to further explore the twilight zone between mathematics and biology in the post-genomics era. Let’s keep the list growing even longer!

 Venue

  • IMS Auditorium
    Institute for Mathematical Sciences, NUS
    3 Prince George's Park
    Singapore 118402
  • Getting to IMS

 Schedule

 
Day 1 - Monday, 28 Nov 2005

09:00am - 09:50am

Registration

09:50am - 10:00am

Welcome and Opening Remarks
Louis Chen, Institute for Mathematical Sciences, NUS
Martti Tammi, National University of Singapore and Karolinska Institutet, Sweden

10:00am - 10:45am

Enhancing the recognition of gene function transfer from model organisms by considering different levels of conservation of co-regulation
Carsten Daub, Karolinska Institutet, Sweden

10:45am - 11:15am

--- Coffee Break ---

11:15am - 12:00nn

Understanding function using in silico and experimental structural information
Prasanna Kolatkar, Genome Institute of Singapore

12:00nn - 12:45pm

Eukaryotic gene expression: the function of actin and actin-associated proteins in transcription
Piergiorgio Percipalle, Karolinska Institutet, Sweden

12:45pm - 02:45pm

--- Lunch break ---

02:45pm - 03:30pm

Protein function prediction from protein interactions
Lim Soon Wong, National University of Singapore

03:30pm - 04:15pm

Bioinformatics workflow integration for biomanufacturing and biosurveillance
Tin-Wee Tan, National University of Singapore

04:15pm - 04:45pm

--- Coffee Break ---

04:45pm - 05:30pm

Cryo-electron tomography of individual protein molecules
Sara Sandin, Karolinska Institutet, Sweden

 

End of Day 1

 
Day 2 - Tuesday, 29 Nov 2005

09:00am - 09:45am

Are complex methods helpful in mapping complex traits (Keynote lecture)
David Siegmund, Stanford University and National University of Singapore

09:45am - 10:30am

Size-dependent Pareto-like distributions in genomics, proteomics and molecular evolution
Vladimir A. Kuznetsov, Genome Institute of Singapore

10:30am - 11:00am

--- Coffee Break ---

11:00am - 11:45am

Comparative genomics of two cyprinid species
Alan Christoffels, Temasek Life Sciences Laboratory, Singapore

11:45am - 12:30pm

Solvation in proteins: insights from atomistic simulations
Chandra Verma, Bioinformatics Institute of Singapore

12:30pm - 02:30pm

--- Lunch break ---

02:30pm - 03:15pm

Inhibition of bacterial genes using expressed RNA and cell-permeable antisense agents
Liam Good, Karolinska Institutet, Sweden

03:15pm - 04:00pm

Filling in the GAPs for cell dynamics control
Boon-Chuan Low, National University of Singapore

04:00pm - 04:30pm

--- Coffee Break ---

04:30pm - 05:15pm

Transcriptional targets of STAST5b in liver
Amilcar Flores, Karolinska Institutet, Sweden

05:15pm - 05:30pm

Closing Remarks

 

End of Symposium

 

 Registration

  • Online pre-registration is now closed. However, you may register as a walk-in participant on the day of the symposium. All are welcome.

 Contacts