Workshop on Genomics
(14 - 17 Nov 2005)

Organizing Committee · Invited Speakers · Overview · Venue · Program
Registration · Contacts

Chair

• David Siegmund (Stanford University and National University of Singapore)

Co-chairs

• Louis Chen (National University of Singapore)
• Louxin Zhang (National University of Singapore)

Members

• Guillaume Bourque (Genome Institute of Singapore)
• Kwok Pui Choi (National University of Singapore)
• Martti Tammi (National University of Singapore)
• Benjamin Yakir (Hebrew University of Jerusalem and National University of Singapore)

• Erik Arner (Karolinska Institutet, Sweden)
• Guillaume Bourque (Genome Institute of Singapore)
• Hock Peng Chan (National University of Singapore)
• I-Shou Chang (National Health Research Institute, Taiwan)
• Kwok Pui Choi (National University of Singapore)
• Yong Kong (National University of Singapore)
• Mark Seielstad (Harvard University and Genome Institute of Singapore)
• David Siegmund (Stanford University and National University of Singapore)
• I-ping Tu (Institute of Statistical Science Academia Sinica, Taiwan)
• Benjamin Yakir (Hebrew University of Jerusalem and National University of Singapore)
• Eric Yap (DSO National Laboratories, Singapore)
• Von Bing Yap (National University of Singapore)
• Heping Zhang (Yale University)
• Nancy Zhang (Stanford University)

 

Overview

Comparison of genomes, within and between species, has the potential to provide knowledge about the role of DNA as the basis for life, evolutionary relationships of different organisms, and the role of genomes in health and disease. Computational biology has a key role to play in genomic research. The core of comparative genome analysis is the establishment of the correspondence between genes or other genomic features in different genomes. By analyzing a genomic sequence or comparing different genomic sequences, one can learn about functional elements and structural organization of genomes. This gives rise to the problems of predicting functional elements, such as genes and transcriptional binding sites, and analyzing structural organization of genomes. Other problems include theoretical support for designing new bioinformatics tools for sequence annotation, exemplified by BLAST and GenScan. The complexity of genome evolution poses many challenges to researchers, who are interested in mathematical modeling, statistical analysis, and development of annotation tools. The workshop will cover gene mapping, sequence analysis, evolutionary genetics, and functional genomics.

• IMS Auditorium
  Institute for Mathematical Sciences, NUS
  3 Prince George's Park
  Singapore 118402
• Getting to IMS

 

Day 1 - Monday, 14 Nov 2005
09:00am - 09:20am	Registration
09:20am - 09:30am	Welcome and Opening Remarks
09:30am - 10:30am	Model selection in irregular problems: applications to gene mapping CGH David Siegmund, Stanford University and National University of Singapore
10:30am - 11:00am	--- Coffee Break ---
11:00am - 12:00nn	The effect of missing information on gene mapping Benjamin Yakir, The Hebrew University of Jerusalem and National University of Singapore   Presentation slides: PDF...
12:00nn - 02:00pm	--- Lunch break ---
02:00pm - 03:00pm	Detection of genes for ordinal traits in nuclear families and a unified approach for association studies Heping Zhang, Yale University   Presentation slides: PPT...
03:00pm - 03:30pm	--- Coffee Break ---
03:30pm - 04:30pm	A Bayes regression approach to array-CGH data I-Shou Chang, National Health Research Institute, Taiwan
	End of Day 1

 

Day 2 - Tuesday, 15 Nov 2005
09:30am - 10:30am	Phylogeny via an EM algorithm based on a general nucleotide substitution model Von Bing Yap, National University of Singapore
10:30am - 11:00am	--- Coffee Break ---
11:00am - 12:00nn	The occurrence and exploitation of simple tandem repeats in bacterial and human genomes Eric Yap, DSO National Laboratories, Singapore
12:00nn - 02:00pm	--- Lunch break ---
02:00pm - 03:00pm	An algorithm for choosing significant PCA components on expression microarrays I-ping Tu, Institute of Statistical Science, Academia Sinica, Taiwan
03:00pm - 03:30pm	--- Coffee Break ---
03:30pm - 04:30pm	Genetic factors influencing Tb susceptibility Mark Seielstad, Harvard University and Genome Institute of Singapore
	End of Day 2

 

Day 3 - Wednesday, 16 Nov 2005
09:30am - 10:30am	Characterization of the maximal score of optimal pairwise local alignments Nancy Zhang, Stanford University   Presentation slides: PDF...
10:30am - 11:00am	--- Coffee Break ---
11:00am - 12:00nn	Asymptotics of the local alignment score for non-affine gap penalties Hock Peng Chan, National University of Singapore
12:00nn - 02:00pm	--- Lunch break ---
02:00pm - 03:00pm	DNPTrapper: an assembly editing tool for finishing of complex repeat regions Erik Arner, Karolinska Institute, Sweden
03:00pm - 03:30pm	--- Coffee Break ---
03:30pm - 04:30pm	Superiority of spaced seeds for genomic sequence comparison Kwok Pui Choi, National University of Singapore
	End of Day 3

 

Day 4 - Thursday, 17 Nov 2005
09:00am - 10:00am	Chromosome rearrangements in evolution and cancer Guillaume Bourque, Genome Institue of Singapore
10:00am - 10:30am	--- Coffee Break ---
10:30am - 11:30am	Statistics of runs of multiletter alphabet and their applications to biological sequence analysis Yong Kong, National University of Singapore
	End of the Workshop

 

Registration

Please complete the registration form (MSWord|PDF|PS) and fax to (65) 6873 8292 or email to ims@nus.edu.sg.

• General enquiries: Secretary (ims@nus.edu.sg)
• Enquires on scientific aspects:  David Siegmund (dos@stat.stanford.edu)

Organizing Committee · Invited Speakers · Overview · Venue · Program
Registration · Contacts