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Workshop on Genomics
(14 - 17 Nov 2005)

Organizing Committee · Invited Speakers · Overview · Venue · Program
Registration · Contacts

 Organizing Committee

Chair

  • David Siegmund (Stanford University and National University of Singapore)

Co-chairs

  • Louis Chen (National University of Singapore)
  • Louxin Zhang (National University of Singapore)

Members

  • Guillaume Bourque (Genome Institute of Singapore)
  • Kwok Pui Choi (National University of Singapore)
  • Martti Tammi (National University of Singapore)
  • Benjamin Yakir (Hebrew University of Jerusalem and National University of Singapore)

 Invited Speakers

  • Erik Arner (Karolinska Institutet, Sweden)
  • Guillaume Bourque (Genome Institute of Singapore)
  • Hock Peng Chan (National University of Singapore)
  • I-Shou Chang (National Health Research Institute, Taiwan)
  • Kwok Pui Choi (National University of Singapore)
  • Yong Kong (National University of Singapore)
  • Mark Seielstad (Harvard University and Genome Institute of Singapore)
  • David Siegmund (Stanford University and National University of Singapore)
  • I-ping Tu (Institute of Statistical Science Academia Sinica, Taiwan)
  • Benjamin Yakir (Hebrew University of Jerusalem and National University of Singapore)
  • Eric Yap (DSO National Laboratories, Singapore)
  • Von Bing Yap (National University of Singapore)
  • Heping Zhang (Yale University)
  • Nancy Zhang (Stanford University)

 

 Overview

Comparison of genomes, within and between species, has the potential to provide knowledge about the role of DNA as the basis for life, evolutionary relationships of different organisms, and the role of genomes in health and disease. Computational biology has a key role to play in genomic research. The core of comparative genome analysis is the establishment of the correspondence between genes or other genomic features in different genomes. By analyzing a genomic sequence or comparing different genomic sequences, one can learn about functional elements and structural organization of genomes. This gives rise to the problems of predicting functional elements, such as genes and transcriptional binding sites, and analyzing structural organization of genomes. Other problems include theoretical support for designing new bioinformatics tools for sequence annotation, exemplified by BLAST and GenScan. The complexity of genome evolution poses many challenges to researchers, who are interested in mathematical modeling, statistical analysis, and development of annotation tools. The workshop will cover gene mapping, sequence analysis, evolutionary genetics, and functional genomics.

 Venue

  • IMS Auditorium
    Institute for Mathematical Sciences, NUS
    3 Prince George's Park
    Singapore 118402
  • Getting to IMS

 Program Schedule

 
Day 1 - Monday, 14 Nov 2005

09:00am - 09:20am

Registration

09:20am - 09:30am

Welcome and Opening Remarks

09:30am - 10:30am

Model selection in irregular problems: applications to gene mapping CGH
David Siegmund, Stanford University and National University of Singapore

10:30am - 11:00am

--- Coffee Break ---

11:00am - 12:00nn

The effect of missing information on gene mapping
Benjamin Yakir, The Hebrew University of Jerusalem and National University of Singapore
  Presentation slides: PDF...

12:00nn - 02:00pm

--- Lunch break ---

02:00pm - 03:00pm

Detection of genes for ordinal traits in nuclear families and a unified approach for association studies
Heping Zhang, Yale University
  Presentation slides: PPT...

03:00pm - 03:30pm

--- Coffee Break ---

03:30pm - 04:30pm

A Bayes regression approach to array-CGH data
I-Shou Chang, National Health Research Institute, Taiwan

 

End of Day 1

 
Day 2 - Tuesday, 15 Nov 2005

09:30am - 10:30am

Phylogeny via an EM algorithm based on a general nucleotide substitution model
Von Bing Yap, National University of Singapore

10:30am - 11:00am

--- Coffee Break ---

11:00am - 12:00nn

The occurrence and exploitation of simple tandem repeats in bacterial and human genomes
Eric Yap, DSO National Laboratories, Singapore

12:00nn - 02:00pm

--- Lunch break ---

02:00pm - 03:00pm

An algorithm for choosing significant PCA components on expression microarrays
I-ping Tu, Institute of Statistical Science, Academia Sinica, Taiwan

03:00pm - 03:30pm

--- Coffee Break ---

03:30pm - 04:30pm

Genetic factors influencing Tb susceptibility
Mark Seielstad, Harvard University and Genome Institute of Singapore

 

End of Day 2

 
Day 3 - Wednesday, 16 Nov 2005

09:30am - 10:30am

Characterization of the maximal score of optimal pairwise local alignments
Nancy Zhang, Stanford University
  Presentation slides: PDF...

10:30am - 11:00am

--- Coffee Break ---

11:00am - 12:00nn

Asymptotics of the local alignment score for non-affine gap penalties
Hock Peng Chan, National University of Singapore

12:00nn - 02:00pm

--- Lunch break ---

02:00pm - 03:00pm

DNPTrapper: an assembly editing tool for finishing of complex repeat regions
Erik Arner, Karolinska Institute, Sweden

03:00pm - 03:30pm

--- Coffee Break ---

03:30pm - 04:30pm

Superiority of spaced seeds for genomic sequence comparison
Kwok Pui Choi, National University of Singapore

 

End of Day 3

 
Day 4 - Thursday, 17 Nov 2005

09:00am - 10:00am

Chromosome rearrangements in evolution and cancer
Guillaume Bourque, Genome Institue of Singapore

10:00am - 10:30am

--- Coffee Break ---

10:30am - 11:30am

Statistics of runs of multiletter alphabet and their applications to biological sequence analysis
Yong Kong, National University of Singapore

 

End of the Workshop

 

 Registration

Please complete the registration form (MSWord|PDF|PS) and fax to (65) 6873 8292 or email to ims@nus.edu.sg.

 Contacts

 

Organizing Committee · Invited Speakers · Overview · Venue · Program
Registration · Contacts