Institute for Mathematical Sciences Event Archive

Workshop on Design of Healthcare Studies

(3-7 July 2017)

Venue: IMS Auditorium
Venue: Department of Statistics and Applied Probability Seminar Room, NUS (Block S16, #06-118, 6 Science Drive 2) (5 & 12 July 2017, Afternoon Session)
PDF Abstracts

Monday, 03 Jul 2017

09:15am - 09:30amRegistration
09:30am - 09:45amOpening Remarks
Kwok Pui Choi, Institute for Mathematical Sciences
Weng Kee Wong, University of California, Los Angeles, USA
09:45amMorning Session Chair: Wei-Yin Loh, University of Wisconsin-Madison, USA
09:45am - 10:45am

Personalised medicine: from hype to scepticism to realism?

(PDF, Video)



Stephen Senn
Luxembourg Institute of Health, Luxembourg
10:45am - 11:15am--- Group Photo & Coffee Break ---
11:15am - 12:15pm

NOC: nonparametric overdose control in phase I clinical trials

(PDF, Video)



Guosheng Yin
The University of Hong Kong, Hong Kong
12:15pm - 02:00pm--- Lunch Break ---
02:00pmAfternoon Session Chair: Keumhee Carriere Chough, University of Alberta, Canada
02:00pm - 03:00pm

Sequential designs for individualized dosing algorithms

(PDF, Video)



Ying Kuen Cheung
Columbia University, USA
03:00pm - 04:00pm

BOIN: a novel platform for designing early phase single-agent and drug-combination clinical trials

(PDF, Video)



Ying Yuan
The University of Texas MD Anderson Cancer Center, USA
04:00pm - 04:30pm--- Coffee Break ---
04:30pm - 05:30pm

Adaptive biomarker trial designs

(PDF, Video)



Adrian Mander
MRC Biostatistics Unit, UK

Tuesday, 04 Jul 2017

09:00am - 09:30amRegistration
09:30amMorning Session Chair: Bee Choo Tai, National University of Singapore, Singapore
09:30am - 10:30am

Learning VA healthcare system through large cooperative studies

(PDF)



Mei-Chiung Shih
Stanford University, USA
10:30am - 11:00am--- Coffee Break ---
11:00am - 12:00pm

Multiplicity considerations in design, data monitoring and analysis of clinical trials with co-primary endpoints

(PDF)



Toshimitsu Hamasaki
Osaka University and National Cerebral and Cardiovascular Center, Japan
12:00pmLunch at Chilli Padi Nonya Cafe (Volunteer and self paid)
Address: 29 Heng Mui Keng Terrace, #06-21 (Ground Level), Singapore 119620
02:00pmExcursion to Gardens by the Bay
Address: 18 Marina Gardens Drive, Singapore 018953

Wednesday, 05 Jul 2017

09:00am - 09:30amRegistration
09:30amMorning Session Chair: Mei-Chiung Shih, Stanford University, USA
09:30am - 10:30am

Optimal designs for comparing (dose response) curves

(PDF, Video)



Holger Dette
Ruhr-Universitaet Bochum, Germany
10:30am - 11:00am--- Coffee Break ---
11:00am - 12:00pm

Equivalence of regression curves

(PDF, Video)



Frank Bretz
Novartis Pharma AG, Switzerland
12:00pm - 02:00pm--- Lunch Reception at IMS ---
02:00pmVenue: Blk S16, S16-06-118, DSAP Seminar Room, Department of Statistics & Applied Probability
Faculty of Science, NUS

Afternoon Session Chair: Weng Kee Wong, University of California, Los Angeles, USA
02:00pm - 03:00pm

Design and analysis of sequential multiple-assignment randomized trials (SMARTs)

(PDF)



Bibhas Chakraborty
Duke-NUS Medical School, Singapore
03:00pm - 04:00pm

Entropy learning for dynamic treatment regimes

(PDF)



Jialiang Li
National University of Singapore, Singapore
04:00pm - 04:30pm--- Coffee Break ---
04:30pm - 05:30pm

Methods on the usage of common controls for genetic association studies



Chaolong Wang
Genome Institute of Singapore, Singapore

Thursday, 06 Jul 2017

09:00am - 09:30amRegistration
09:30amMorning Session Chair: Ying Lu, Stanford University, USA
09:30am - 10:30am

A brief overview of adaptive enrichment with subpopulation selection in precision medicine

(PDF)



Sue-Jang Wang
U.S. Food and Drug Administration, USA
10:30am - 11:00am--- Coffee Break ---
11:00am - 12:00pm

Adaptive enrichment trials for biomarker-guided treatments

(PDF)



Noah Simon
University of Washington, USA
12:00pm - 02:00pm--- Lunch Break ---
02:00pmAfternoon Session Chair: Noah Simon, University of Washington, USA
02:00pm - 03:00pm

Sequential multiple assignment randomization trials with enrichment design

(PDF, Video)



Donglin Zeng
University of North Carolina at Chapel Hill, USA
03:00pm - 04:00pm

Designs of dose escalation studies in phase I oncology trials

(PDF, Video)



Ying Lu
Stanford University, USA
04:00pm - 04:30pm--- Coffee Break ---
04:30pm - 05:30pm

A nonparametric bayesian basket trial design

(PDF, Video)



Peter Mueller
University of Texas at Austin, USA

Friday, 07 Jul 2017

09:00am - 09:30amRegistration
09:30amMorning Session Chair: Frank Bretz, Novartis Pharma AG, Switzerland
09:30am - 10:30am

Optimal linear combination of biomarkers for multi-category diagnosis

(PDF)



Yi-Hau Chen
Institute of Statistical Science Academia Sinica, Taiwan
10:30am - 11:00am--- Coffee Break ---
11:00am - 12:00pm

Matched learning for estimating optimal individualized treatment rules from clinical trials and observational studies

(PDF)



Yuanjia Wang
Columbia University, USA
12:00pm - 02:00pm--- Lunch Break ---
02:00pmAfternoon Session Chair: Jialiang Li, National University of Singapore, Singapore
02:00pm - 03:00pm

N-of-1 trials for individualized patient care

(PDF)



Keumhee Carriere Chough
University of Alberta, Canada
03:00pm - 04:00pm

The promise and peril of healthcare analytics: two examples in healthcare resource planning and frequent flyer identification

(PDF)



Yik Ying Teo
National University of Singapore, Singapore
04:00pm - 04:30pm--- Coffee Break ---
04:30pm - 05:30pm

Analysis of massive genome, exposome and phenome data



Xihong Lin
Harvard University, USA